Kodexia Kodexia is XtalPi’s closed-loop siRNA discovery platform combining generative AI, first-principles biological modeling through the proprietary siFormer architecture, and automated high-throughput laboratories. It unifies sequence design, chemical modification, extrahepatic delivery optimization, experimental validation, and IP strategy into a single computational-experimental workflow, delivering nearly 3x design efficiency and first-round in vivo hit rates exceeding 50% across programs.