UPGRADE is an ARPA-H program focused on improving cybersecurity for network-connected equipment in hospitals. It envisions a software suite that helps hospital teams assess vulnerabilities and the possible effects of security updates through simulated hospital environments. Its four technical areas cover a vulnerability mitigation platform, digital twins of hospital equipment, automated vulnerability detection, and development of defenses. The program brings together work by equipment manufacturers, cybersecurity specialists, and hospital IT staff, with the goal of enabling security measures while limiting disruption to patient care.