UNIQUE is an ARPA-H program exploring whether quantum-derived observables can reveal biologically meaningful information that conventional anatomical, functional, or molecular imaging may miss. Its work is organized into two technical areas: developing physical systems to generate and measure quantum observables in biomedical settings, and building computational methods for reconstruction, interpretation, and fusion with other imaging data. The program aims to test whether this information can complement existing imaging; it does not present the approach as a replacement for current imaging methods.