STREAM is an ARPA-H program focused on reducing herbicide exposure while helping farmers manage weeds and maintain agricultural productivity. Its research areas include developing next-generation chemical and biological weed treatments; precision and nonchemical weed control, such as targeted application and autonomous weeders; continuous monitoring of herbicides and related chemicals; and methods to remove or degrade agricultural chemicals in soil and water. The program also aims to reduce chemical residues reaching crops and waterways and to protect workers, consumers, and surrounding ecosystems.