SPECTRA is an ARPA-H research program focused on understanding autism and supporting autistic people across the lifespan. It aims to combine biological, clinical, behavioral, and real-world information to study factors associated with individual developmental, health, communication, and functional trajectories. The program seeks solutions across analysis, modeling, precision intervention, and enabling technologies. Its stated goals include improving assessment beyond clinic-based observation, supporting individualized intervention choices, and developing accessible tools for communication, quality of life, and real-world measurement.