REST is an ARPA-H research funding program focused on making sleep quality measurable and treatable at home. It seeks proposals in two technical areas: systems that measure sleep-related physiology and diagnose poor sleep with clinical fidelity, and noninvasive closed-loop systems that adapt interventions to a person’s physiology during the night. A separate program element supports sleep-health modeling, data harmonization, benchmarking, integration, and independent verification. The intended outcome is personalized sleep assessment and intervention informed by health-relevant sleep features.