Precision Surgical Interventions (PSI) is an ARPA-H program focused on improving what surgeons can see during operations. It seeks technologies to visualize tumor edges and distinguish them from healthy tissue, as well as tools to reveal critical anatomy such as nerves and blood vessels. The program describes possible approaches including bedside or in-body imaging devices, drawing on fields such as microscopy, chemistry, optics, biomedical engineering, and machine learning. Its intended applications include cancer surgery and other procedures where clearer visualization may help surgeons remove targeted tissue while avoiding harm to nearby structures.