GLIDE is an ARPA-H program focused on developing physical and pharmacological therapies that target abnormal lymphatic structure and function. Its work spans biomaterials, interventional radiology, minimally invasive surgery, imaging, compression, and targeted pharmacologic, gene, and cell therapies. The program aims to improve understanding of lymphatic dysfunction and develop treatment options for primary lymphatic disease and other chronic conditions associated with lymphatic dysfunction. GLIDE also incorporates patient and caregiver perspectives through Discovery Duos, which pair early-career investigators with patient or caregiver ambassadors.