Functional Repair of Neocortical Tissue: restoring function after permanent brain damage.
FRONT is an ARPA-H research program focused on restoring function after damage to the neocortex, the brain region involved in sensory perception, motor control, and higher-order cognition. It aims to develop methods for forming normal tissue from non-specialized cells, grafting that tissue, and evaluating its integration with healthy neocortex, tissue structure, and functional recovery. ARPA-H selected a multidisciplinary performer team led by Sophrosyne Biosciences to develop precursor tissue grafts intended to integrate with the adult brain.
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