FASTPASS is an ARPA-H program focused on reducing harm from substandard or contaminated medicines. It aims to develop rapid, non-destructive tools that assess pharmaceutical shipments through their packaging in near real time at ports, warehouses, and distribution centers. Its two technical areas address through-packaging sensing and analytics and models for interpreting sensor data. The program brings together non-contact spectroscopy, artificial intelligence and machine learning, pharmaceutical chemistry, and hardware engineering to support decisions about product quality and safety.