BioStabilization Systems (BoSS) is an ARPA-H research and development program focused on preserving cell-based biologics at room temperature. It brings together approaches from nature-inspired biology and materials science to develop ways to stabilize and restore cells, alongside processing systems designed to reduce stress on cells during manufacturing. The program’s goal is to develop methods to produce, store, and transport cell-based medicines without relying on ultra-cold storage. Awarded teams are working on distinct approaches, and an independent partner is tasked with assessing preserved products and preservation systems.