BIOmolecular Grammar for protein Aggregation Modulation and Intervention: detecting and repairing early protein dysfunction.
BIOGAMI is an ARPA-H research and development program focused on intrinsically disordered proteins, whose flexible regions can misfold or aggregate and contribute to disease. The program brings together protein science and computational approaches to study the patterns, or “grammar,” that guide protein behavior. Its teams are developing experimental and computational tools to detect early protein dysfunction and design interventions that may restore healthy protein states. Initial work includes neurodegenerative diseases and other conditions, with research spanning protein behavior, disease-relevant models, and potential diagnostic and therapeutic approaches.
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