The ARPA-H Biomedical Data Fabric Toolbox is a research and development program intended to make biomedical data easier to collect, connect, explore, and reuse across research and clinical sources. Its stated focus includes computer-readable data collection, multi-source analysis, data exploration, and access that accounts for privacy and security. The program’s performer teams are developing varied tools, including AI-assisted curation, data discovery, and data integration approaches. Initial work includes cancer and rare-disease data, with the goal of making approaches useful across disease areas.