ADVOCATE is an ARPA-H research and development program aimed at developing agentic AI for cardiovascular care, initially focused on people with heart failure and those who have had heart attacks. Its planned patient-facing agents would support care between visits, including appointments, medication changes, diet, exercise, and escalation to a human care team. The program also aims to develop a supervisory AI system to monitor deployed agents for safety and effectiveness, and to test implementation across varied health-care settings.