Software engineer
- Location
- San Francisco
- Type
- Full time
- Compensation
- $150k-$200k
- Posted
- 2 days ago
Join a team building useful software. Work closely with engineering and design to turn new ideas into products.
Find roles through people you trust, and message a verified founder or page admin about your interest.
Genome Valley, Hyderabad, India | Full-Time
As Senior Principal Scientist / Principal Scientist, Peptide Synthesis at Enveda, you will build and lead our peptide synthesis group from the ground up. You will set up the lab, define synthesis, purification and QC standards, and grow a team of 3-4 chemists who turn sequences designed by our project teams into high-purity, well-characterised peptides for therapeutic programmes. The role starts hands-on at the bench and moves toward leadership as the team matures.
Synthesise linear, cyclic, lipidated and modified peptides by Fmoc SPPS (manual, microwave and automated), including orthogonal on-resin chemistry for branching and cyclisation
Troubleshoot difficult sequences (aggregation, racemisation, aspartimide formation) and give the design team early feedback on synthetic feasibility
Guide preparative RP-HPLC purification, interpret HPLC and LC-MS data, and decide between re-purification, re-synthesis and release
Set up the lab: specify and qualify synthesisers and lyophilisers, write SOPs, and partner with CROs/CDMOs for scale-up
Hire, train and mentor 3-4 chemists; plan workloads, run technical reviews and build a strong safety culture
PhD in organic or peptide chemistry with 10-12 years of hands-on peptide synthesis experience, including 2-3+ years leading or mentoring a team
Deep Fmoc SPPS expertise (manual, automated and microwave) with demonstrated success on long, hydrophobic, cyclic, multi-disulfide and lipidated peptides
Strong LC-MS interpretation skills and experience scaling from mg to hundreds of mg or gram scale
GLP-1-type or macrocyclic peptide experience, or experience setting up a peptide lab, is a strong plus
Clear communicator who can explain the limits of peptide chemistry to non-chemists